|
KMID : 0923620210210010004
|
|
Immune Network
2021 Volume.21 No. 1 p.4 ~ p.4
|
|
|
Current Status of COVID-19 Vaccine Development: Focusing on Antigen Design and Clinical Trials on Later Stages
|
|
Lee Pu-Reum
Kim Chang-Ung
Seo Sang-Hawn
Kim Doo-Jin
|
|
|
Abstract
|
|
|
|
The global outbreak of coronavirus disease 2019 (COVID-19) is still threatening human health, economy, and social life worldwide. As a counteraction for this devastating disease, a number of vaccines are being developed with unprecedented speed combined with new technologies. As COVID-19 vaccines are being developed in the absence of a licensed human coronavirus vaccine, there remain further questions regarding the long-term efficacy and safety of the vaccines, as well as immunological mechanisms in depth. This review article discusses the current status of COVID-19 vaccine development, mainly focusing on antigen design, clinical trials in later stages, and immunological considerations for further study.
|
|
|
KEYWORD
|
|
|
COVID-19, Vaccines, Prefusion-stabilized, VAERD, Antibody-dependent enhancement, Pre-existing immunological memory
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|